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Inappropriate ADH Secretion Associated With Bronchogenic Carcinoma

Aruna C. Daniels, MB. BS; Sudhansu Chokroverty, MB, BS, MRCP; Kevin D. Barron, MD

Arch Neurol. 1969;21(1):15-24.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ATIENTS harboring malignant neoplasms may develop neurological and endocrinological disorders in the absence of metastases to the nervous system or endocrine glands.¹ The resulting clinical syndromes have been referred to as the "remote" or "nonmetastatic" effects of malignant tumors. The exact incidence of these complications has not been determined. Croft and Wilkinson² state that nonmetastatic neurological syndromes develop in 2% to 16% of carcinomas, and of these, 65% are neuromuscular in type. The incidence of neurological involvement is highest with pulmonary malignancies. Although hypotheses implicating infectious, nutritional immunological, metabolic, and toxic factors have been suggested.^1,3-7 the precise biological basis of these remote effects has not been determined.

We provide here a clinical and anatomical report of a man who presented with dementia, developed inappropriate secretion of the antidiuretic hormone (ADH), and died six months later in status epilepticus. General autopsy revealed a bronchogenic carcinoma which had not . . . [Full Text PDF of this Article]

Author Affiliations
Chicago and Hines, Ill

From the Neurology Service and the Neuropathology Research Section, Veterans Administration Hospital, Hines, Ill, and the departments of neurology and psychiatry, Northwestern University Medical School, Chicago. Dr. Daniels is now with the Department of Pathology, University of Chicago, Chicago. Dr. Chokroverty is now with the Department of Neurology, Chicago Medical School, Chicago. Dr. Barron is now with the Department of Neurology, Albany Medical College of Union University, Albany, NY.

Footnotes
Submitted for publication Feb 5, 1969; accepted March 11.

Reprint requests to the Department of Neurology, Albany Medical College of Union University, Albany, NY 12208 (Dr. Barron).

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