 |
|
Effect of Oral Contraceptives on Experimental Demyelinating Disease
Barry G. Arnason, MD;
David P. Richman, MD
Arch Neurol. 1969;21(1):103-108.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
AS THE USE of oral contraceptives has spread, certain hazards associated with their use have come to light.1,2 In the case of the human demyelinating disease, multiple sclerosis, no data have come forth as to whether oral contraceptives influence its course favorably, unfavorably, or at all. The point is of some moment to women with the disease, many of whom are terrified by the prospect of pregnancy and of the consequences which may be in store for them because of pregnancy.
Experimental allergic encephalomyelitis (EAE), an acute demyelinating disease of auto-allergic etiology, is produced readily in experimental animals, and mimics multiple sclerosis in many of its clinical and pathologic features. Whether or not it provides a reasonable model for multiple sclerosis is a matter of dispute, but on the basis that it may do so, a study of EAE in rats fed various oral contraceptive preparations, as well
. . . [Full Text PDF of this Article]
Author Affiliations
Boston
From the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston (Dr. Arnason) and John Hopkins University School of Medicine. Baltimore (Dr. Richman). Dr. Richman is now with Jacobi Hospital, Albert Einstein School of Medicine, New York.
Footnotes
Submitted for publication March 4, 1969; accepted March 17.
Reprint requests to the Department of Neurology, Massachusetts General Hospital, Boston 02114 (Dr. Arnason).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
