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Lipids in Cerebrospinal FluidXII. In Multiple Sclerosis and Retrobulbar Neuritis
Wallace W. Tourtellotte, MD, PhD;
Armin F. Haerer, MD
Arch Neurol. 1969;20(6):605-615.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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THE CONCEPT that cerebrospinal fluid (CSF) may contain products of central nervous system (CNS) disintegration or metabolism was discussed as early as 1910 by Mott1 and later more extensively by Mestrezat.2 The basis for these authors' suggestion was the fact that the lipid content of nervous tissue was high. For this reason the quantitative determination of lipids in the CSF may serve as a diagnostic test in demyelinating diseases, such as multiple sclerosis (MS).
In an earlier publication from this laboratory we have outlined a scheme for the determination of lipids in the CSF and described the normal lipid profile.3 In another report we have described our preliminary findings of alterations in the CSF lipid profile in MS.4 At this time, we present a detailed summary of our findings of the changes in the CSF lipid profile in patients with MS and with retrobulbar neuritis.
Methods
. . . [Full Text PDF of this Article]
Author Affiliations
Ann Arbor, Mich
From the Department of Neurology, University of Michigan Medical Center, Ann Arbor, Mich. Dr. Haerer is now with the University Medical Center, Jackson, Miss.
Footnotes
Submitted for publication May 25, 1968; accepted Jan 27, 1969.
Reprint requests to the Department of Neurology, University of Michigan Medical Center, Ann Arbor, Mich 48104 (Dr. Tourtellotte).
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