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An Electron Microscopic Study

Ronald D. Macdonald, MD; Neill B. Rewcastle, MB, ChB; John G. Humphrey, FRCP(C)

Arch Neurol. 1969;20(6):565-585.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

EREDITARY intermittent flaccid paralysis of skeletal muscle is at present classified into three types on the basis of the changes in the serum potassium during the paralytic attack. The hypokalemic form was the first to be clinically recognized, and is the most common of the three variants, more than 600 cases having been described in the literature by 1959.¹ The clinical manifestations of this disease will not be detailed here as many reviews are available.^2-5 Worthy of emphasis, however, is that permanent proximal muscle weakness may occur. This feature was first noted by Oppenheim⁶ in 1891 and was later thought to be a variant of spinal muscular atrophy occurring in conjunction with periodic paralysis.⁷ However, it has now become apparent that permanent myopathic weakness is not uncommon, and not dependent upon severe or repeated paralytic attacks.^8-10

The histological appearance of the skeletal muscle in such . . . [Full Text PDF of this Article]

Author Affiliations
Toronto

From the Division of Neuropathology, departments of pathology (Drs. Macdonald and Rewcastle) and medicine (Dr. Humphrey), University of Toronto and the Toronto General Hospital.

Footnotes
Submitted for publication Dec 7, 1968; accepted Dec 26.

Read before the First Canadian Congress of the Neurological Sciences, Toronto, June 1966.

Reprint requests to 100 College St, Toronto 2 (Dr. Rewcastle).

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