This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (110)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Light and Electron Microscopic Study

CPT Sydney S. Schochet, Jr, MC; LTC John M. Hardman, MC; Peter P. Ladewig, MD; Kenneth M. Earle, MD

Arch Neurol. 1969;20(5):548-553.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN THE ADULT, motor neuron disease or amyotrophic lateral sclerosis can be subdivided into several groups on the basis of clinical, pathologic, and epidemiologic features.¹ The histologic changes observed in the classic sporadic cases include nonspecific degeneration and loss of motor neurons in the spinal cord, brain stem, and cerebral cortex. Demyelination of the pyramidal tracts often accompanies the neuronal losses.² A familial variant further characterized by demyelination of the posterior columns and spinocerebellar tracts has been reported.³ In a few residual motor neurons from these cases, Hirano et al⁴ described accumulations of hyalinized material, occasionally with acidophilic cores that resemble Lewy bodies. In still another variant, the amyotrophic lateral sclerosis and Parkinsonism-dementia complex on Guam, neurofibrillary tangles have been observed in the anterior horn cells.⁵

This report presents light and electron microscopic observations from an unusual sporadic case of motor neuron disease characterized by . . . [Full Text PDF of this Article]

Author Affiliations
USAR, USA, Washington, DC; Charleston, WVa; Washington, DC

From the Neuropathology Branch (CPT Schochet; LTC Hardman; and Dr. Earle) and the Laboratory of Skeletal Muscle Research (LTC Hardman), Armed Forces Institute of Pathology, Washington, DC, and the Department of Pathology, Charleston General Hospital, Charleston, WVa (Dr. Ladewig).

Footnotes
Submitted for publication Dec 12, 1968; accepted Dec 26.

Reprint requests to Neuropathology Branch, Armed Forces Institute of Pathology, Washington, DC 20305 (Dr. Earle).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?