This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Tetsuji Santa, MD

Arch Neurol. 1969;20(5):479-489.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

RECENTLY, progressive muscular dystrophies and other types af myopathies^1-6 have been attracting interest in biochemical, physiologic, and morphologic studies. Although the pathogenesis has not been elucidated, study of the nature of myopathies has been accelerated with current electron microscopic techniques.^7-10

In 1960, Van Breemen⁹ reported that early vacuolation of the sarcoplasmic reticulum (SR) was seen as the primary lesion of muscular dystrophy in both light and electron microscopic studies. Platzer and Chase¹¹ examined muscle of dystrophic mice and found alterations in the muscle fiber, especially disappearance of the sarcolemma, which were observed before clinical manifestations. They concluded that the initial defect might involve the sarcolemma. Fisher et al¹² described mitochondrial changes as the earliest defect. Ultrastructural studies have also revealed new diseases, such as central core disease,¹³ myotubular myopathy,¹⁴ and megaconial myopathy.^15,16 Ultrastructural observations in McArdles disease¹⁷ and familial hypokalemic . . . [Full Text PDF of this Article]

Author Affiliations
Fukuoka, Japan

From the Second Department of Anatomy and the Department of Neurology, Kyushu University, Fukuoka, Japan.

Footnotes
Submitted for publication Feb 27, 1968; accepted Oct 23.

Presented in part at the 23rd scientific meeting of the Japanese Society of Electron Microscopy, Fukuoka, Japan, May 1967.

Reprint requests to Department of Neurology, Neurological Institute, Kyushu University, Fukuoka, Japan.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?