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A Clinical and Experimental Study

E. F. Vastola, MD; R. Homan, MD; A. Rosen, MD

Arch Neurol. 1969;20(4):430-439.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THERE is in the literature a number of observations suggesting that moderate hypothermia, 34 to 25 C might have a permissive or facilitatory influence on focal electrical seizures in the neocortex of mammals. Swinyard and Toman¹ found that the threshold current for electroconvulsive seizures in unanesthetized rats decreased and the seizure duration increased during general hypothermia; the susceptibility to seizures induced by intraperitoneal pentylenetrazol and picrotoxin also increased during hypothermia. In a study² of rats anesthetized with tribromoethanol or urethane, spontaneous unit activity in the sensorimotor cortex was found to increase when the temperature in that area was lowered 3 to 4 C by cooling the cortical surface. In unanesthetized rabbits,³ repetitive electrical stimulation of the lateral geniculate body was found to induce paroxysmal activity in the striate cortex which spread over the entire cortex and continued for a long time under general hypothermia below 30 . . . [Full Text PDF of this Article]

Author Affiliations
Brooklyn, NY

From the Division of Neurology, State University of New York, College of Medicine, Brooklyn, NY.

Footnotes
Submitted for publication July 30, 1968; accepted Oct 19.

Reprint requests to Division of Neurology, State University of New York, College of Medicine, 450 Clarkson Ave, Brooklyn, NY 11203 (Dr. Vastola).

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