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Alterations Induced in Animals by High Pressure Oxygen

John W. Bean, PhD, MD; Nelson E. Leatherman, PhD

Arch Neurol. 1969;20(4):396-405.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

EARLIER studies¹ on unanesthetized rats have shown that the toxic action of O₂ at high pressure (OHP) on the central nervous system has been associated with cyclic synchronous and asynchronous changes in the O₂ availability in localized regions of the brain. The nature of these regional PO₂ changes suggest they might possibly be due to or associated with regional changes in cerebral blood flow (CBF). The present experiments were carried out in an attempt to get further and more direct evidence concerning such changes in CBF in the rat. The heated thermocouple technique, a refinement of the method used in earlier blood flow studies² has been used for continuously recording any regional changes in blood flow from chronically implanted flow sensors. Various modifications of this method originally designed by Gibbs^3,4 to investigate the blood flow in the internal jugular vein of man were . . . [Full Text PDF of this Article]

Author Affiliations
Ann Arbor, Mich

From the Department of Physiology, The University of Michigan, Ann Arbor, Mich.

Footnotes
Submitted for publication Aug 22, 1968; accepted Oct 25.

Read in part before the Federation of American Societies for Experimental Biology, April 1968, Atlantic City, NJ.

Reprint requests to the Department of Physiology, The University of Michigan, Ann Arbor, Mich 48104 (Dr. Bean).

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