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Regional Cerebral Blood Flow in ManI. A Study of the Xenon 133 Washout Method
E. James Potchen, MD;
David O. Davis, MD;
Thomas Wharton, BS;
Rex Hill, MS;
Juan M. Taveras, MD
Arch Neurol. 1969;20(4):378-383.
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THE CLINICAL determination of the regional cerebral blood flow (rCBF), based upon the inert gas washout technique of Kety and Schmidt1 and developed by Lassen, Ingvar, Hø-Rasmussen et al2-5 has become an established procedure in many laboratories. This technique is currently advocated as the most physiologic means to measure regional blood flow and, therefore, is assuming increasing importance as an adjunct to carotid arteriography.
Using a two compartment model, many investigators have calculated the washout curve as the sum of two exponents which has been said to estimate regional flow distribution between the white and gray matter, while others have used Zierler's6 mean  H flow calculations (f= A, where = the partition coefficient, H = the difference in height of the curve from 0-10 minutes, and A = the area under the curve). Both of these calculations require knowledge of the maximum height of the curve (Hmax). We
. . . [Full Text PDF of this Article]
Author Affiliations
St. Louis
From the Edward Mallinckrodt Institute of Radiology (Drs. Potchen and Davis, and Mr. Wharton) and the Biomedical Computer Laboratory, Washington University School of Medicine (Drs. Hill and Taveras) St Louis.
Footnotes
Submitted for publication Oct 2, 1968; accepted Nov 25.
Reprint requests to Mallinckrodt Institute of Radiology, 510 S Kingshighway, St. Louis 63110 (Dr. Potchen).
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