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Isak Gath, MD

Arch Neurol. 1969;20(4):354-357.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PROGRESSIVE myoclonic epilepsy was first described by Unverricht¹ and Lundborg.² It is characterized by onset in childhood or adolescence of grand mal seizures, myoclonic jerks, and dementia, all of which tend to progress ad mortem.

The disorder is often familial.

Dawson^3,4 showed that evoked cortical responses to sensory stimuli were abnormal in patients with myoclonic epilepsy. The amplitude of the responses could be ten times larger than the amplitude in control individuals.

The aim of this study was to investigate the effect of some drugs on the somatonsensory evoked potentials in two patients with progressive myoclonic epilepsy.

Materials and Methods

A rectangular pulse with a frequency of 1/sec and lasting 0.5 msec was applied to the median nerve at the wrist, the strength of the stimulus being 30% higher than the motor threshold (50 to 80 v).

Averaged cortical responses evoked by 20 stimuli were recorded . . . [Full Text PDF of this Article]

Author Affiliations
Oslo

From the Laboratory of Clinical Neurophysiology, Rikshospitalet, Oslo.

Footnotes
Submitted for publication Nov 6, 1968; accepted Dec 23.

Read in part before the 11th Scandinavian Congress of Clinical Neurophysiology, Linkoping, Sweden, May 1968.

Reprint requests to Department of Neurology, Rikshospitalet, Oslo.

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