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Evidence of a Nonfocal Site of Action of Carbon Dioxide on Cerebral Circulation

E. Skinhøj, MD; O. B. Paulson, MD

Arch Neurol. 1969;20(3):249-252.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN A series of papers in this journal last year Shalit and his co-workers discussed "Carbon Dioxide and Cerebral Circulatory Control." From three series of experiments on anesthetized dogs they concluded that the well-known CO₂ effect on the cerebral blood flow (CBF increases when the arterial CO₂ pressure [Pco₂] increases) was due to receptors sensitive to CO₂ and not to pH,₁ that changes in the arterial Pco₂ had no direct effect on the cerebral vessels,² and that destruction in the upper part of the medulla, pons, and the lower part of mesencephalon abolished the CBF response to changes in the arterial Pco₂.³ These experiments suggest the existence of a CO₂-sensitive center in the brain stem regulating the cerebral vascular resistance in the hemispheres via a neurogenic mechanism.

Two different problems are involved in this hypothesis: is the CO . . . [Full Text PDF of this Article]

Author Affiliations
Copenhagen

From the Department of Neurology and Clinical Physiology, Bispebjerg Hospital, Copenhagen.

Footnotes
Submitted for publication Aug 1, 1968; accepted Oct 11.

Reprint requests to Department of Neurology, Bispebjerg Hospital, Copenhagen (Dr. Skinhøj).

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