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Effect of Lesions of the Intralaminar Nuclei

P. Bédard, MD; L. Larochelle, MD; A. Parent, MSc; L. J. Poirier, MD, PhD

Arch Neurol. 1969;20(3):239-242.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE EXISTENCE of intralamino-striatal fibers, previously suggested by different workers,^1-3 has been more firmly established by recent studies involving both morphological^4-6 and electrophysiological⁷ criteria.

The fact that the electrical stimulation of nucleus centrum medianum (CM) induces the release of minute amounts of dopamine from the caudate nucleus led to the suggestion that the intralamino-striatal fibers are dopaminergic.⁸ This hypothesis is supported by the fact that the inhibition of unit activity in the caudate nucleus produced by electrical stimulation of nucleus centrum medianum is similar to the inhibitory effect obtained by applying dopamine on the surface of the caudate nucleus.⁹

On the other hand, it has been shown that lesions of the ventromedial tegmental area of the midbrain are associated with an almost complete depletion of dopamine and serotonin in the corresponding striatum in the monkey¹⁰ and the cat.¹¹ Therefore it was considered . . . [Full Text PDF of this Article]

Author Affiliations
Quebec

From the Laboratoire de Neuro-psychiatrie expérimentale, Département de Physiologie, Faculté de Médecine, Université Laval, Quebec. Dr. Larochelle and Dr. Bédard are holders of a fellowship of the Medical Research Council of Canada.

Footnotes
Submitted for publication Oct 3, 1968; accepted Nov 9.

Reprint requests to Laboratoire de Neuro-psychiatrie expérimentale, Faculté de Médecine, Université Laval, Quebec (Dr. Poirier).

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