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Measurement by Electroimmunodiffusion

Stuart A. Schneck, MD; Henry N. Claman, MD

Arch Neurol. 1969;20(2):132-139.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

MORE than 25 years have passed since Kabat and co-workers,¹ using the Tiselius electrophoresis method, first noted that the cerebrospinal fluid (CSF) -globulin content was elevated in some patients with multiple sclerosis and neurosyphilis. Many methods have been described subsequently in the search for a rapid, simple, and reliable test which would quantitate the CSF immunoglobulins. The standard for accuracy for all these procedures has been the immunochemical method of Kabat et al.² Few clinical laboratories use this test, however, for it is time consuming, expensive, and complex. In 1966, a method of electroimmuno-diffusion (EID) suitable for use with minute volumes of unconcentrated CSF was described by Hartley et al.³ It is the purpose of this paper to relate our clinical experience with this test, to compare it with other methods for quantitation of CSF immunoglobulins, and to summarize the available information regarding the value of CSF . . . [Full Text PDF of this Article]

Author Affiliations
Denver

From the Division of Neurology (Dr. Schneck) and the Division of Clinical Immunology (Dr. Claman), University of Colorado Medical Center, Denver.

Footnotes
Submitted for publication June 29, 1968; accepted Sept 23.

Reprint requests to 4200 E Ninth Ave, Denver 80220 (Dr. Schneck).

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