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T. S. Elizan, MD; L. Ajero-Froehlich, MD; A. Fabiyi, PhD; A. Ley, MS; J. L. Sever, MD, PhD

Arch Neurol. 1969;20(2):115-119.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE association between congenital central nervous system (CNS) developmental anomalies and viral infection occurring in pregnancy has been definitely shown in man with rubella virus^1-4 and cytomegalovirus.^5-9 Microcephaly, hydrocephaly, anencephaly, encephalomyelocele, meningomyelocele, and Dandy-Walker syndrome with obstructive hydrocephalus, have all been described in congenital rubella. The CNS involvement may also be in the form of an encephalomyelitis, and mental retardation is common. Like rubella, human cytomegalovirus can induce significant CNS pathology. This may take the form of a meningoencephalitis, microcephaly, hydrocephaly, microgyria, porencephaly, or periventricular calcifications. Mental retardation, seizures, and other signs of focal cerebral dysfunction are neurological features of survivors of congenital cytomegalic inclusion disease. Other viruses such as mumps,^10,11 herpes simplex,^12-15 rubeola¹⁶ and influenza^17,18 have been linked with human congenital abnormalities, not specifically of the central nervous system. Evidence of causal relation, however, between these viruses and the congenital abnormalities is tenuous. . . . [Full Text PDF of this Article]

Author Affiliations
Bethesda, Md

From the Perinatal Research Branch, National Institute of Neurological Diseases and Blindness, National Institute of Health, Bethesda, Md.

Footnotes
Submitted for publication Sept 20, 1968; accepted Oct 5.

Reprint requests to Department of Neurology, Mount Sinai School of Medicine, Fifth Ave and 100th St, New York 10029 (Dr. Elizan).

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