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Creatine Phosphokinase, Aldolase, and Lactic Dehydrogenase

Arthur H. Wolintz, MD; Lawrence D. Jacobs, MD; Nicholas Christoff, MD; Misu Solomon, PhD; Norman Chernik, MD

Arch Neurol. 1969;20(1):54-61.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE clinical significance of enzymology in neurological disorders is as yet uncertain. A number of enzymes have been studied both in serum and in cerebrospinal fluid (CSF). In general, these studies have been limited to a single enzyme and have not included a comparison of the serum and CSF activities of the same enzymes.^1-12 Much more needs to be known about the levels of different enzymes in CSF, their relation with one another, and their relation to the serum levels of the same enzymes.

In the present study, we compare the CSF and serum activities of the enzymes creatine phosphokinase (CPK), lactic dehydrogenase (LDH), and aldolase (ALD) in a series of patients suffering from acute vascular disorders of the brain. These enzymes are well-known in clinical enzymology and have been studied to some extent in the CSF. CPK in particular is an attractive enzyme because it is found . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the departments of neurology (Drs. Jacobs, Christoff, and Chernik) and clinical pathology (Dr. Solomon), The Mount Sinai Services, City Hospital at Elmhurst and The Mount Sinai School of Medicine (Drs. Jacobs, Christoff, Chernik, and Solomon), New York, and the Department of Neurology, Maimonides Medical Center, Brooklyn (Dr. Wolintz).

Footnotes
Submitted for publication July 26, 1968; accepted Sept 6.

Reprint requests to Division of Neurology, Maimonides Medical Center, 4802 10th Ave, Brooklyn, New York 11219.

Read in part before the annual meeting of the American Neurological Association, Washington, DC, June 19, 1968.

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