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Basic Patterns and Their Clinical Significance

Abraham Towbin, MD

Arch Neurol. 1969;20(1):35-43.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

TWO BASIC forms of hypoxic brain damage make their appearance in the fetus and newborn. The lesions, located in the cerebrum, distributed through the cortical and deep structures, are not of random occurrence. The cerebral damage evolves in precise patterns; the location of lesions is governed by the gestational age of the fetus or neonate at the time of the hypoxic event. This temporal factor is of significance not only in determining the anatomic pattern of the cerebral damage, but correspondingly, has a direct bearing on the ultimate form of the neurologic defect in infants who survive. Accordingly, the findings here offer an organic basis for correlating the occurrence of gestational complications, particularly prematurity, with the presence clinically of cerebral palsy, mental retardation, and other nervous system defects in infants who survive.

Traditionally the occurrence of hypoxic damage in the neonatal brain has been minimized. . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Department of Neuropathology, Harvard University Medical School and the Department of Pathology, Boston University School of Medicine, Boston.

Footnotes
Submitted July 26, 1968; accepted Sept 12.

Read before the 44th Annual Meeting of the American Association of Neuropathologists, Washington, DC, June 14, 1968.

Reprint requests to Rm 312, 15 Stoughton St, Boston 02118 (Dr. Towbin).

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