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Report of a Cortical Biopsy and Review of the Recent Literature

Mary M. Herman, MD; Peter R. Huttenlocher, MD; Klaus G. Bensch, MD

Arch Neurol. 1969;20(1):19-34.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN 1952 and 1954, Seitelberger described four children with a degenerative disorder of the nervous system of early onset, characterized by the widespread distribution of axonal swellings in the central nervous system.^1,2 He pointed out the resemblance of this disorder to Hallervorden-Spatz disease, and in a later publication he proposed the name "neuroaxonal proteid dystrophy."³ Cowen and Olmstead reported in 1963 two similar cases as "infantile neuroaxonal dystrophy," and emphasized the uniqueness of this clinical and pathologic entity.⁴ Since then, there have been several additional descriptions of infantile neuroaxonal dystrophy (hereafter abbreviated as INAD).^4-12 A rather characteristic clinical picture has emerged, which is distinctive enough to allow for a presumptive diagnosis of this disorder during life.⁹ Recently we have had the opportunity to study by cerebral biopsy another child with clinical findings strongly suggestive of INAD. The present case has provided us with an opportunity . . . [Full Text PDF of this Article]

Author Affiliations
New Haven, Conn

From the departments of pathology (Drs. Herman and Bensch) and pediatrics and the Division of Neurology (Dr. Huttenlocher), Yale University School of Medicine, New Haven, Conn.

Footnotes
Submitted for publication July 20, 1968; accepted, Aug 27.

Reprint requests to Department of Pathology, Stanford University School of Medicine, Stanford, Calif 94305 (Dr. Herman).

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