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HAROLD KOENIG, M.D.

AMA Arch Neurol. 1960;2(4):463-475.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Pyrimidine nucleotides are precursors of nucleic acids; several are also known to be co-enzymes in carbohydrate and phospholipid metabolism.¹ We have attempted to assess the physiological and metabolic roles of pyrimidine nucleotides in the central nervous system by the intrathecal administration of pyrimidine antimetabolites. Neurological disturbances have been reported with the use of several such substances. 6-Azauracil, an analogue of uracil, causes confusional states, progressing to coma and diffuse high-voltage, slow waves in the EEG in man^2,3; these effects are reversible. Massive doses of this analogue produce ataxia and similar EEG changes in rats.⁴ 5-Hydroxyuridine and 5-aminouridine, analogues of uridine, produce transient somnolence and seizures in rats upon intraventricular injection.⁵

Orotic acid is an effective precursor of acid-soluble and nucleic acid pyrimidines in many organs,⁶ the central nervous system included.^7,8 Therefore, 5-fluoro-orotic acid (FO), a structural analogue of orotic acid (Fig. 1) was . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Neurology Service and the Radio-isotope Service, Veterans Administration Research Hospital, and the Department of Neurology and Psychiatry, Northwestern University Medical School.

Footnotes
Accepted for publication Dec. 17, 1959.

Presented in part at the 84th Annual Meeting of the American Neurological Association, June, 1959.

Assisted by grants from the Atomic Energy Commission (Contract No. 11-1 [89]) and the National Institute for Neurological Diseases and Blindness of the U.S. Public Health Service (B-1456 and B-1456a).

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