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Cerebral Hemorrhage in Leukemia
SIGMUND N. GROCH, M.D.;
GEORGE P. SAYRE, M.D.;
FRANK J. HECK, M.D.
AMA Arch Neurol. 1960;2(4):439-451.
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Although hemorrhage of the brain is a well-known potential complication in every case of leukemia, there are few detailed reports in the literature that deal with the incidence of this complication, and the controversy over the basic cause of such hemorrhage remains unsettled. Is it primarily a perivascular infiltration of the brain substance, or is it primary hemorrhage consisting of blood and leukemic cells?
Therefore, it was thought worth while to review a series of cases of leukemia with the hope of answering the following questions: 1. How often does cerebral hemorrhage occur in a given group of leukemic patients? 2. In what subgroup of leukemia does hemorrhage occur most frequently? 3. Is there any direct correlation between disturbances in coagulation and the appearance of cerebral hemorrhage? 4. What parts of the brain are involved most frequently? 5. What is the incidence of neurologic symptoms? 6. What is the microscopic
. . . [Full Text PDF of this Article]
Author Affiliations
Rochester, Minn.
Fellow in Medicine, Mayo Foundation (Dr. Groch). Section of Pathologic Anatomy (Dr. Sayre), and Section of Medicine (Dr. Heck), Mayo Clinic and Mayo Foundation. The Mayo Foundation, Rochester, Minn. is a part of the Graduate School of the University of Minnesota.
Footnotes
Accepted for publication Dec. 4, 1959.
Abridgment of thesis submitted by Dr. Groch to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Medicine.
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