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Effect of Anticonvulsant Drugs on Cortical and Subcortical Seizure Discharges in Cats
ROBERT R. J. STROBOS, M.D.;
EDWARD V. SPUDIS, M.D.
AMA Arch Neurol. 1960;2(4):399-406.
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The mechanism by which anticonvulsant drugs prevent seizures is largely unknown. Both biochemical and electrophysiological techniques have been used to seek information regarding inhibition of convulsive discharges. In this study, after-discharges were evoked by electrical stimulation of the ectosylvian gyrus, the hippocampus, the amygdaloid nucleus, and the septal region. Threshold voltage, duration, spread, and frequency characteristics of the evoked after-discharges were studied before and after the administration of anticonvulsants. Diphenylhydantoin (Dilantin), trimethadione (Tridione), and phenobarbital were the drugs used.
Methods
Mature cats were anesthetized with ether administered through an endotracheal tube. Electrodes were implanted by the stereotactic method, through 3 mm. burr holes. Stainless-steel wire electrodes inserted into insulated, No. 22 needle stock were used for acute experiments. The final 0.5 mm. of the wire core was bared and separated from the uninsulated rim of the sheath by 0.3 mm. In the chronic experiments, insulated, paired strands of stainless steel
. . . [Full Text PDF of this Article]
Author Affiliations
Winston-Salem, N.C.
From the Section of Neurology, Bowman Gray School of Medicine of Wake Forest College.
Footnotes
Accepted for publication Dec. 4, 1959.
This study was supported in part by the United Medical Research Foundation of North Carolina.
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