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I. Effects of Sleep, Arousal, and Drugs

JOSEPH C. WHITE, M.D.; EDUARDO EIDELBERG, M.D.; JOHN D. FRENCH, M.D.

AMA Arch Neurol. 1960;2(4):376-383.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

In previous studies French, Gernandt, and Livingston¹¹ observed that upon direct repetitive stimulation different areas of the monkey's cerebral cortex displayed different thresholds for the induction of electrical after-discharges. The motor cortex had the lowest and the occipital the highest threshold for seizure induction with this technique. A subsequent study by Eidelberg, Konigsmark, and French⁹ revealed that this differential susceptibility to seizure induction was paralleled by differences in the amplitude of the direct cortical responses (DCR) to single-shock local electrical stimulation. The maximum amplitudes were encountered in the motor cortex, while minimum deflections were found in the occipital cortex; intermediate values were present in other areas of the convexity. Recently Kandel, Spencer, and Brinley¹⁸ have reported very large responses to be elicited by a similar technique on the dorsal hippocampal surface, one of the most epileptogenic structures. Chang,^5,6 Clare and Bishop,⁷ and others have . . . [Full Text PDF of this Article]

Author Affiliations
Long Beach, Calif.

Postdoctoral Trainee, Mental Health Training Program (Dr. White); present address: Division of Neurology, Jefferson Medical College, Philadelphia.

Department of Anatomy, University of California at Los Angeles School of Medicine, and the Veterans Administration Hospital, Long Beach, Calif.

Footnotes
Accepted for publication Dec. 17, 1959.

Supported by U.S. Public Health Service Grants No. B-611 and No. 2M-6415, and a grant from the Los Angeles County Epilepsy Society.

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