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Drug (Tremorine)-Induced Tremor in the CatAbolition by Differential Transections of the Neuraxis
W. W. KAELBER, M.D.;
E. G. HAMEL, Ph.D.
AMA Arch Neurol. 1960;2(3):338-340.
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Introduction
A method of studying possible anatomical substrates involved in the production of a rest-type tremor has been provided by use of the drug Tremorine (1,4-dipyrrolidino-2-butyne)2 in the cat. Reports dealing with an analysis of the tremor-producing properties of this compound have been primarily those of Everett et al.1 These authors indicated that decerebration (presumably intercollicular) in the mouse, rat, and rabbit (cat, dog, and monkey not specifically indicated) and decerebellation in the dog failed to eliminate the tremor. In addition, spinalcord section prevented tremor below, but not above, the level of the section.
In order to determine the amount of brain essential for the "specific" effect of this drug, cats were studied after transections at various levels between spinal cord and forebrain. The results and relevant correlations of this approach are herein described. Attention is particularly directed toward the following section on "Methods" because a clear concept
. . . [Full Text PDF of this Article]
Author Affiliations
Iowa City
From the Departments of Neurology and Anatomy, State University of Iowa.
Footnotes
Accepted for publication Nov. 11, 1959.
Aided in part by U.S. Public Health Grant M675.
Tremorine was generously supplied by Abbott Laboratories, North Chicago, Ill.
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