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Cerebrospinal Fluid Enzymes as a Function of AgeIts Effect upon the Significance of Elevated Values in Various Diseases of the Nervous System
RAYMOND F. HAIN, M.D.;
JANET NUTTER, B.S.
AMA Arch Neurol. 1960;2(3):331-337.
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In establishing control values of cerebrospinal fluid glutamic-oxalacetic transaminase, it was observed that the values for 5 of 25 control spinal fluids were considerably higher than the values for the remaining 20. It was not certain whether this indicated unrecognized cerebral disease, was merely a sampling error introduced by the relatively small number of control fluids, or was a true expression of the biological variation of the cerebrospinal fluid glutamic-oxalacetic transaminase levels. The clinical records of each of the five patients with high values were scrutinized for evidence of recent or old disease of the nervous system. In one of the five cases a diagnosis of chronic brain syndrome had been made on a previous hospital admission, and it seemed wise, therefore, to remove this case from the controls. In none of the remaining four cases was there present or past evidence of disease of the nervous system. It was
. . . [Full Text PDF of this Article]
Author Affiliations
Seattle
From the Department of Pathology, University of Washington School of Medicine.
Footnotes
Accepted for publication Nov. 3, 1959.
Presented in part at the Annual Meeting of the American Society of Clinical Pathologists, Chicago, Nov. 1-8, 1958.
Supported by funds from Initiative 171 Fund of the State of Washington, Boeing United Good Neighbor Fund, and United Cerebral Palsy Association of King County, Wash.
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