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Effect of Norepinephrine on Cerebral Hemodynamics in Severe Hypotension
JOSEPH F. FAZEKAS, M.D.;
ANDREE THOMAS, M.D.;
JULIA V. V. JOHNSON, M.S.;
WILLIAM K. YOUNG, M.S.
AMA Arch Neurol. 1960;2(3):305-308.
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Although vasopressor agents are frequently employed for the correction of hypotension, the effects of their administration on cerebral hemodynamics and metabolism in this circulatory disorder have not been adequately studied. Since the brain is one of the organs most vulnerable to reduction in oxygen delivery, such studies gain added significance. In a previous communication, Moyer et al.1 described the cerebral hemodynamic responses resulting from the continuous infusion of metaraminol (Aramine) and norepinephrine; with a rise in pressure from normotensive to hypertensive levels, the rate of cerebral blood flow decreased. In subjects with hypotension induced by ganglionic blocking agents, the administration of pressor agents was associated with an increase of cerebral blood flow to normal values. In this report, the effect of intravenously administered norepinephrine on cerebral hemodynamics and oxygen consumption in patients with hypotension resulting from or associated with a variety of clinical disorders is presented.
. . . [Full Text PDF of this Article]
Author Affiliations
Boston
From the District of Columbia General Hospital, Washington, D.C., and the Department of Neurology, New England Center Hospital, Boston.
Footnotes
Accepted for publication Oct. 13, 1959.
This investigation was supported in part by a research grant (PHS B-178) from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, Public Health Service.
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