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Hyperosmolarity (Hypernatremia) and Azotemia Induced by the Administration of Urea
BURTON L. WISE, M.D.
AMA Arch Neurol. 1960;2(2):160-162.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Urea has proved to be a useful agent in lowering intracranial pressure and brain bulk.1,2 This agent has generally been administered intravenously in a 30% solution. Urea has been administered orally in repeated daily doses for several weeks and, in a few instances, for several months.3
In the case to be described, urea was administered by gastric tube in amounts of 150 to 400 ml. of 30% solution for eight days. The osmotic diuresis which occurred appears to have been responsible for the hyperosmolarity and azotemia which developed.
Report of a Case
A 70-year-old woman, left-handed, began to have convulsive seizures in 1948. One year later she underwent a laparotomy for exploration of the common bile duct. She developed a vascular collapse during the procedure and remained in coma for two days following the operation. When she recovered, she had total amaurosis of the left eye. In retrospect
. . . [Full Text PDF of this Article]
Author Affiliations
San Francisco
From the Division of Neurological Surgery, University of California Medical Center.
Footnotes
Received for publication Aug. 20, 1959.
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