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J. R. BERGEN, Ph.D.; R. B. PENNELL, Ph.D.; H. FREEMAN, M.D.; H. HOAGLAND, Ph.D.

AMA Arch Neurol. 1960;2(2):146-150.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Heath et al.¹ reported several years ago that a protein substance extracted from the blood of schizophrenic patients would produce transient psychotic symptoms when injected into nonpsychotic persons. Comparable protein fractions from normal subjects were without such effects. Recently, Winter and Flataker² have stated that injections of plasma and serum from psychotic patients affect the performance of trained rats in a manner quantitatively, and possibly qualitatively, different from that elicited by samples from nonpsychotic subjects. We have used the Winter and Flataker test³ to investigate possible differences in plasma protein fractions from psychotic and from nonpsychotic persons when they are injected intraperitoneally into rats.

Methods

Young male Holtzman rats, weighing approximately 80 gm., are placed on restricted rations and taught to climb a vertical rope 5 ft. high. The hungry rats, when placed on a platform near the base of the apparatus, learn to run quickly . . . [Full Text PDF of this Article]

Author Affiliations
Shrewsbury, Mass.

From the Worcester Foundation for Experimental Biology (Dr. Bergen, Staff Member; Dr. Hoagland, Executive Director), The Protein Foundation (Dr. Pennell, Director), and Medfield State Hospital (Dr. Freeman, Director of Research).

Footnotes
Submitted for publication Aug. 14, 1959.

The following members aided in various aspects of these studies: Dr. Milton Raskin, Mrs. C. Quist, and Mr. A. Zilinsky, Worcester State Hospital, and Mrs. L. Perkins, Worcester Foundation for Experimental Biology.

This study was supported in part by grants from The Ford Foundation, from Grant M1322 (C2) of the U.S. Public Health Service, and from the Scottish Rite Committee for Research on Dementia Praecox, National Association of Mental Health, and from Grant H-2226 of the U.S. Public Health Service.

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