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Prevention of Cerebral Edema in the Rat After Prolonged Circulatory Arrest

Stanley Prusiner, MD; Sidney K. Wolfson, Jr., MD

Arch Neurol. 1968;19(6):623-627.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

HYPOXIA and ischemia are well documented as causal agents of cerebral edema and irreversable brain damage.^1-7 Since the permanent deleterious effects of lowered O₂ tension can, to some extent, be protected against by hypothermia, it was of interest to explore the influence of low temperature on the development of cerebral edema during circulatory arrest. In the experiments on rats presented here, deep hypothermia was induced by the closed vessel method of Andjus and resuscitation was accomplished with ultrashortwave diathermy in the early stage of rewarming.^8-11 Significant brain edema was not observed after one hour of circulatory arrest with hypothermia of 3 to 5 C, while moderate hypothermia of 20 C without hypoxia was observed to cause a contraction of the brain.

Materials and Methods

Forty-six male, Sprague-Dawley rats weighing 150 to 200 gm were used. Twelve of these had hypothermic circulatory arrest while under hypercapnic . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia.

Footnotes
Submitted for publication July 31, 1968; accepted Aug 9.

Reprint requests to Director Surgical Research, Michael Reese Hospital and Medical Center, Chicago 60616 (Dr. Wolfson).

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