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A Rapid Method for Identifying the Schwann Cell and Axonal Cytoplasm

John A. Morgan-Hughes, MD; W. King Engel, MD

Arch Neurol. 1968;19(6):613-617.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE EXAMINATION of single nerve fibers in teased preparations has contributed to the study of peripheral nerve lesions both in man^1-3 and in experimental animals.^4-10 This technique has proved to be particularly suitable for demonstrating segmental demyelination where the early stages of myelin destruction, beginning at the nodes of Ranvier, and the late stages of remyelination, can be studied in greater detail than with any other method of preparation at the light microscope level.¹¹ Although the techniques currently available for staining single fibers, using osmium tetroxide or one of the sudan dyes, are excellent for detecting early changes in the myelin sheath, they provide only limited and indirect information about the behavior of the Schwann cell or of the axon. In view of the importance of the Schwann cell in the formation and maintenance of the myelin and the implication that it is the primary . . . [Full Text PDF of this Article]

Author Affiliations
Bethesda, Md

From the Medical Neurology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Bethesda, Md 20014. Dr. Morgan-Hughes is currently at the National Hospital, Queen Square, London.

Footnotes
Submitted for publication July 14, 1968; accepted, July 31.

Reprint requests to Medical Neurology Branch, NINDB, NIH, Bethesda, Md 20014 (Dr. Engel).

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