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Relation of EEG and Seizures to Phenobarbital in Serum
F. Buchthal, MD;
O. Svensmark, PhD;
H. Simonsen, MD
Arch Neurol. 1968;19(6):567-572.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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AN EARLIER study showed that diphenylhydantoin must attain a certain concentration in the serum if seizures are to be controlled and paroxysmal activity in the electroencephalogram (EEG) diminished1; thus, the serum level of diphenylhydantoin is an important guide to proper dosage. The relation between the dose of phenobarbital and its effect is difficult to assess clinically because three to five weeks elapse from the onset of medication until a constant serum concentration is reached.2 In the study reported here the correlation between the concentration of phenobarbital in the serum, the incidence of paroxysmal abnormalities in the EEG, and the anticonvulsant effect was investigated in patients with grand mal seizures.
Patients
The study was comprised of 13 hospitalized patients; seven females and six males, the criterion of selection being a high incidence of paroxysmal activity in the EEG. Twelve patients had grand mal, 11 as the sole form
. . . [Full Text PDF of this Article]
Author Affiliations
Copenhagen; Dianalund, Denmark
From the Institute of Neurophysiology, University of Copenhagen (Drs. Buchthal and Svensmark) and the Filadelfia Colony, Dianalund, Denmark (Dr. Simonsen).
Footnotes
Submitted for publication April 5, 1968; accepted April 17.
Reprint requests to Institute of Neurophysiology, Juliane Maries Vej 36, 2100 Cophenhagen ø, Denmark (Dr. Buchthal).
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