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Report of a Case

CPT Fredrick J. Seil, MC; CPT Sydney S. Schochet, Jr., MC; Kenneth M. Earle, MD

Arch Neurol. 1968;19(5):494-502.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PREVIOUS descriptions of Alexander's disease have generally been of cases in young children.^1-8 The clinical picture most often associated with this disease has been one of developmental retardation and enlargement of the head. Vogel and Hallervorden,⁹ however, described a case in a 15-year-old girl that began with weakness of the left leg and foot at age 7 and progressed to spasticity and contractures of the lower extremities, eventual weakness of the upper extremities, and development of blurred vision, nystagmus, dysarthria, and dysphagia. The brain was atrophic, weighing 990 gm at autopsy. Stevenson,¹⁰ referring to this case, stated that the patient "presented the picture that one would think might be multiple sclerosis." Rewcastle¹¹ presented a case of a 26-year-old man whose symptoms began at age 14 with weakness of the legs, followed by arm weakness, incontinence, diplopia, and difficulty with speech and swallowing. Findings on examination included . . . [Full Text PDF of this Article]

Author Affiliations
USAR, USAR Washington, DC

From the Neuropathology Branch, Armed Forces Institute of Pathology, Washington, DC.

Footnotes
Submitted for publication June 29, 1968; accepted Aug 5.

Reprint requests to Laboratory of Pathology at AFIP, Washington, DC 20305 (Dr. Earle).

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