This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Permeability Changes Influencing the Concentration of Sugars and Macromolecules in Cerebrospinal Fluid

Leon D. Prockop, MD; Robert A. Fishman, MD

Arch Neurol. 1968;19(5):449-463.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE cerebrospinal fluid (CSF) changes characteristically associated with bacterial meningitis include an increase in protein and a decrease in glucose content. The former change is usually attributed to inflammatory changes in the meninges in association with a generalized increase in the permeability of the membranes which comprise the "blood-CSF barrier."¹ This permeability change presumably results in the greater diffusion of plasma proteins into CSF. The decrease in glucose content has been attributed to glycolysis by phagocyting polymorphonuclear leukocytes in the presence of bacteria,² as evidenced by increased concentrations of lactic acid in purulent fluids.³ Another factor has been suggested, namely, that a variety of meningeal disorders may be associated with an alteration in the transfer of glucose between blood and CSF.^4-6 Glucose transfer has been shown to be dependent upon a membrane carrier system, which has the characteristics of facilitated diffusion.⁷

These studies were . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia; San Francisco

From the Departments of Neurology, Columbia University, New York, and the University of Pennsylvania, Philadelphia (Dr. Prockop), and the University of California, San Francisco (Dr. Fishman).

Footnotes
Submitted for publication July 5, 1968; accepted July 18.

Read in part before the annual meeting of the American Neurological Association, Washington, DC, June 1966, and the Western Society for Clinical Research, Carmel, Calif, January 1967.

Reprint requests to Department of Neurology, University of California Medical Center, San Francisco 94122 (Dr. Fishman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?