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Immunologic Reactions After Cortical Lesions in Rabbits
Florry Proctor Bowen, PhD
Arch Neurol. 1968;19(4):398-402.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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WHILE studying the Arthus reaction in monkey brain and using aluminum hydroxide as an adjuvant in combination with foreign proteins applied to the cortex, Kopeloff et al1 discovered that aluminum hydroxide alone could produce recurrent convulsive seizures. Although these authors became famous for this discovery, it is interesting to consider some of the observations made in relation to the use of immunological techniques in the study of experimental epilepsy. They reported that sensitization of the brain with a single foreign protein such as egg white (without adjuvant) placed on the brain of monkeys generally sensitized to egg white or egg white injected intravenously into animals in which egg white had been previously applied to the cortex, yielded acute seizures. These were defined as single attacks or a series of attacks which usually terminated within one week of onset. Kopeloff et al1 examined the sera of
. . . [Full Text PDF of this Article]
Author Affiliations
Los Angeles
From the Department of Medical Microbiology and Immunology, UCLA Medical Center, Los Angeles. Dr. Bowen is now at the Columbia University Presbyterian Medical Center, New York.
Footnotes
Submitted for publication Feb 19, 1968; accepted March 13.
Read before the National EEG Meeting, Denver, October 1966.
Reprint requests to the Parkinsons' Disease Foundation, Neurological Institute, Columbia University Presbyterian Medical Center, 710 W 168th St, New York (Dr. Bowen).
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