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Report of Cases

Roger N. Rosenberg, MD; Donald L. Schotland, MD; Robert E. Lovelace, MD; Lewis P. Rowland, MD

Arch Neurol. 1968;19(4):362-376.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

UNTIL 1950 the syndrome of progressive ptosis and ophthalmoplegia was generally considered to be neurogenic in origin as indicated by the designation "progressive nuclear ophthalmoplegia." This concept was based upon two cases^1,2 in which there were neuronal abnormalities in postmortem study of the oculomotor nuclei. In 1951, however, Kiloh and Nevin³ concluded that the ocular signs were due to myopathy because of histological abnormalities in the medial rectus muscle in one case; they considered the neural changes of earlier cases to be insignificant, and they introduced the terms "ocular myopathy" or "ocular dystrophy." Their view dominated the subsequent literature, and six later autopsy cases^4-9 also supported the concept of myopathy.

In our own experience, however, the same syndrome has sometimes been associated with a variety of neurological abnormalities. There have also been several reports^10-31 of similar cases associated with neural disease. These combined disorders raise . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Neurological Clinical Research Center, Neurological Institute, Columbia-Presbyterian Medical Center, and the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York. Drs. Schotland and Rowland are now at the Hospital of the University of Pennsylvania, Philadelphia.

Footnotes
Submitted for publication April 18, 1968; accepted May 7.

Reprint requests to Spiller Neurological Unit, University of Pennsylvania Hospital, Philadelphia 19104 (Dr. Rowland).

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