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Etiology and Significance

Murray A. Falconer, M Ch, FRCS, FRACS; David C. Taylor, MB, DPM

Arch Neurol. 1968;19(4):353-361.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THERE is now general agreement^1-3 that in about 50% of institutionalized epileptic patients who die of natural causes, an autopsy will disclose a lesion. This was first demonstrated macroscopically in 1825, in 9 out of 18 cases, by Bouchet and Cazauvieilh,¹ who called it Ammon's horn sclerosis (synonyms—sclerosis of the cornu Ammonis and hippocampal sclerosis). Its histopathology was subsequently described in 1880 by Sommer.⁴ This lesion has also been called "incisural sclerosis"⁵ and "pararhinal sclerosis".^6,7 Both these terms, however, have now acquired rather misleading connotations, one of difficult birth and the other of olfactory perception. We therefore prefer the simpler term "mesial temporal sclerosis" (MTS) because the sclerotic process usually involves other structures, such as the amygdala and uncus, as well as the hippocampus, and because the term which has since been adopted by others is purely descriptive without etiological or functional implications⁸ (Figure). . . . [Full Text PDF of this Article]

Author Affiliations
London

From the Guy's-Maudsley Neurosurgical Unit, De Crespigny Park, London.

Footnotes
Submitted for publication Sept 12, 1967; accepted May 20, 1968.

Read before the Section on Nervous and Mental Diseases at the 116th Annual Meeting of the American Medical Association, Atlantic City, NJ, June 20, 1967; La Ligue Française Contre L'Epilepsie, Paris, Oct 3, 1967; and at a Clinical Lecture, Guy's Hospital, London, Jan 4, 1968.

Dr. Taylor is now at the Human Development Research Unit, The Park Hospital For Children, University of Oxford, Headington, Oxford.

Reprint requests to Guy's-Maudsley Neurosurgical Unit, De Crespigny Park, London S. E. 5, (Dr. Falconer).

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