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Report of a Case

Shukuro Araki, MD; Akira Terao, MD; Isamu Matsumoto, MD; Tomiko Narazaki, Phar B; Yoshigoro Kuroiwa, MD

Arch Neurol. 1968;19(3):315-320.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

NEUROMUSCULAR disorders in the course of hyperthyroidism are recognized^1-3 and presently include exophthalmic ophthalmoplegia,⁴ thyrotoxic myopathy,^5-10 myasthenia gravis,^3,11,12 and periodic paralysis.^13,14 Chronic thyrotoxic myopathy is most common but the mechanism of muscular dysfunction is obscure.

The clinical features of chronic thyrotoxic myopathy are due to progressive weakness, more pronounced in proximal muscles. Disability may be mild or severe. Muscular wasting is frequently seen, and muscle cramps also occur occasionally.¹⁵

McArdle¹⁶ described a patient with a lifelong history of cramps after muscular exercise and postulated that this disorder was due to a defect in muscle glycogen break-down. Subsequently, Schmid et al,¹⁷ Mommaerts et al,¹⁸ and Pearson et al¹⁹ found that muscle phosphorylase was lacking in similar patients. Since then, absence of muscle phosphorylase in additional cases has been confirmed.^20,21 Recently, Tarui et al,²² and Layzer et al,²³ described . . . [Full Text PDF of this Article]

Author Affiliations
Fukuoka City, Japan

From the departments of neurology and biochemistry (Dr. Matsumoto), Kyushu University, Fukuoka, Japan. Dr. Terao is now at Okayama University.

Footnotes
Submitted for publication Jan 15, 1968; accepted March 27.

Reprint requests to Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka City, Japan (Dr. Araki).

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