This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

An Electron Microscopic Study

R. D. Macdonald, MD; N. B. Rewcastle, MB, ChB; J. G. Humphrey, FRCP (C)

Arch Neurol. 1968;19(3):274-283.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

HYPERKALEMIC periodic paralysis has been recognized as a distinct disorder only since 1951 when several generations of a family were described suffering from episodes of periodic paralysis without an accompanying fall in the serum potassium.¹ Gamstorp further elucidated the main clinical features of the disease and established that the serum potassium was elevated during the paralytic attack.^2,3 Later reports emphasized the common occurrence of myotonic features^4,5 and that permanent myopathic weakness involving the abdominal and proximal limb girdle muscles may occur.^6,7 Early muscle biopsies failed to reveal significant histopathological alterations.^8,9 However, more recent reports have demonstrated infrequent central vacuolation of minor proportions with some nonspecific myopathic features^7,10; these changes are similar to, but less marked, than those in hypokalemic periodic paralysis. Publications on the fine structure of skeletal muscle in this condition have shown few abnormalities¹¹ or vacuoles possibly arising from the . . . [Full Text PDF of this Article]

Author Affiliations
Toronto

From the Division of Neuropathology, Department of Pathology (Drs. Macdonald and Rewcastle), and the Department of Medicine (Dr. Humphrey), University of Toronto and the Toronto General Hospital.

Footnotes
Submitted for publication Dec 12, 1967; accepted May 3, 1968.

Reprint requests to 100 College St, Toronto 2 (Dr. Rewcastle).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?