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Mechanisms of Interaction and Regional Variations in Capacity for Synchronous Discharges

Elliott M. Marcus, MD; C. Wesley Watson, MD

Arch Neurol. 1968;19(1):99-116.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

WE HAVE previously reported the results of a series of experiments in the cat concerning the interaction of acute relatively large bilateral epileptogenic foci in homologous areas of cerebral cortex^1,2 (predominantly posterior sigmoid and suprasylvian gyri). In the intact animal, this interaction often resulted in the rapid production of persistent synchronous and symmetrical patterns of bilateral discharge including 21/2 to 31/2 cycles per second (cps) spike-slow wave complexes. Relevant behavioral concomitants of these bilateral discharges resembled some of the clinical phenomena observed in patients with idiopathic petit mal or grand mal seizures during similar bilateral discharges: bilateral facial muscle and forelimb myoclonus, transient suspension or imperfect continuation of a repetitive act, and occasional generalized convulsive seizures.

Investigations of the underlying anatomical pathways involved in this interaction of bilateral cortical foci indicated the significant role of the corpus callosum. Synchrony of bilateral discharge failed to occur after total . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Department of Neurology, New England Medical Center Hospitals and Tufts University School of Medicine Boston.

Footnotes
Submitted for publication Oct 2, 1967; accepted Dec 27.

Read in part before the American Electroencephalographic Society, Oct 9, 1966, Denver, and published in part in Transactions of the American Neurological Association, 1967.

Reprint requests to 171 Harrison Ave, Boston 02111 (Dr. Marcus).

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