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An Autoradiographic Study With 65Zn

Ove Hassler, MD; Rune Söremark, DMD

Arch Neurol. 1968;19(1):117-120.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT is well known that the hippocampal region of the brain of most mammals is rich in some heavy metals. In general, the methods used to study the occurrence of heavy metals in this tissue have been the dithizon technique ad modum Maske¹ and the sulfide-silver procedure by Timm.² The dithizon method is relatively specific for zinc. The sulfide-silver procedure does not differentiate between various heavy metals. The positive staining reaction indicating localization of metals notably zinc has mainly been confined to the layer of the mossy fibers in the H₃ to H₅ portions of the hippocampus.^3,4 The physiological significance of the occurrence of this zinc is not known.

Chemical analysis of the rabbit brain⁵ has shown slightly higher concentrations of zinc in the hippocampus (13.9µg/gm of fresh tissue) than in the cerebellum (10.8), the cerebral cortex (10.5), or the midbrain (8.8). An . . . [Full Text PDF of this Article]

Author Affiliations
Umeå, Sweden

From the departments of pathology II (Dr. Hassler), and of prosthetics (Dr. Söremark), University of Umeå, Sweden.

Footnotes
Submitted for publication Feb 2, 1968; accepted Feb 19.

Reprint requests to Department of Pathology II, Umeå 6, Sweden (Dr. Hassler).

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