This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Effects on the Spinal Cord of Parabiont Rats

George Kury, MD; Shields Warren, MD; Rosanna N. Chute, MA

Arch Neurol. 1968;18(6):703-707.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ONLY a limited amount of data exist on the effect of radiation on neurons. The central nervous system (CNS) is generally fairly resistant to radiation therapy. This is indeed fortunate as a fair number of lesions in man best treated by radiation occur in close proximity to the brain and spinal cord.

Histopathological studies on changes resulting from radiation of the CNS have usually been limited to investigation of effects of localized x-irradiation. Inferior performance in running time was found in Sprague-Dawley rats irradiated with 2,500 rads or 5,000 rads to the forebrain. On histologic examination of the animals, necrotic foci were found in the brain, the neuroglial cells were somewhat hypertrophied, and there was moderate radiation change in blood vessels.¹ Vogel² found minimal damage to neurons in monkeys receiving over 2,500 roentgens (R) with a sharp increase in injury from 5,000 R. The granular cells were . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Cancer Research Institute, New England Deaconess Hospital, Boston.

Footnotes
Submitted for publication Feb 8, 1968; accepted Feb 19.

Reprint requests to 194 Pilgrim Road, Boston 02215 (Dr. Kury).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?