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Carl F. Essig, MD; Robert C. Lam, MD

Arch Neurol. 1968;18(6):626-632.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THERE IS little doubt that alcohol (ethanol) is one of the most commonly abused drugs of addiction in the United States. In addition to other harmful effects of its excess use, alcohol can cause physical dependence. This aspect of alcohol abuse is important from a medical viewpoint because the abstinence reactions that can result from such dependence are not uncommon and some of them can be serious. Thus, delirium tremens has a mortality rate as high as 15%.¹

In the past there was some doubt that alcohol could cause physical dependence. It was thought by some that "rum fits" or delirium tremens were associated with alcohol intoxication rather than being precipitated by its withdrawal after physical dependence had developed. The careful clinical observations of Victor and Adams,¹ and the controlled experiments of Isbell et al² in man confirmed that these clinical states are precipitated by . . . [Full Text PDF of this Article]

Author Affiliations
Lexington, Ky

From the Section of Experimental Neurology, Addiction Research Center (Dr. Essig), and the Department of Surgery, Clinical Research Center (Dr. Lam), National Institute of Mental Health, Lexington, Ky.

Footnotes
Submitted for publication Nov 16, 1967; accepted Dec 20.

Reprint requests to PO Box 2000, Lexington, Ky 40507 (Dr. Essig).

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