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II. Neurologic, Genetic, and Electrophysiologic Findings in Various Neuronal Degenerations

Peter James Dyck, MD; Edward H. Lambert, MD

Arch Neurol. 1968;18(6):619-625.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE companion paper¹ on this topic considered the inherited hypertrophic neuropathies in which peroneal muscle weakness and atrophy is prominent. In those disorders, a symmetric neurogenic weakness and atrophy is an early and prominent feature, conduction velocities of peripheral nerves are markedly reduced, and histologic studies reveal abnormalities of Schwann cells and of myelinization. This paper considers cases of neuronal degeneration in which peroneal muscle weakness and atrophy is prominent. In this group of cases, conduction velocities of nerves are either normal or slightly low and nerve biopsies show no evidence of segmental demyelinization or hypertrophy of nerve. In some of these cases there is probably selective degeneration of anterior horn and dorsal root ganglion cells with degeneration of axons; in other cases the site of degeneration of the neuron is less well understood—a metabolic disorder of the neuron may be the cause of degeneration of nerve terminals . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, Minn

From the Mayo Clinic and Mayo Foundation Section of Neurology (Dr. Dyck) and Physiology (Dr. Lambert).

Footnotes
Submitted for publication Sept 28, 1967; accepted Jan 8, 1968.

Reprint requests to Mayo Clinic, 200 First St SW, Rochester, Minn 55901 (Dr. Dyck).

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