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II. Effect on Penicillin-Induced Seizures in the Cat

Sydney Louis, MD; Henn Kutt, MD; Fletcher McDowell, MD

Arch Neurol. 1968;18(5):472-477.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT HAS BEEN shown previously that diphenylhydantoin given intravenously reaches cerebral tissue preferentially and very rapidly, irrespective of the rate of administration.¹ The actual concentration accumulating in cerebral tissue is directly related to the dose infused.

Assuming a similar relationship between the dose and the cerebral concentration of diphenylhydantoin in the human, the drug ought to be effective in stopping status epilepticus, provided (A) it is given in sufficient quantity and (B) diphenylhydantoin is effective in stopping seizures. Murphy and Schwab² reported good results in three patients. Wallis et al³ using the intravenous infusion of 1 gm of diphenylhydantoin, found that seizures could be halted in 16 of 31 patients with status epilepticus.

On the other hand, Rand et al⁴ found that intravenous diphenylhydantoin had no effect on the direct cortical response, the augmented direct cortical response, or induced epileptic cortical activity in paralyzed, anesthetized . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Second (Cornell) Neurology Service, Bellevue Hospital and the Department of Neurology, Cornell University Medical College, New York.

Footnotes
Submitted for publication Nov 30, 1967; accepted Dec 16, 1967.

Reprint requests to Second (Cornell) Neurology Service, Bellevue Hospital, First Ave and 26th St, New York 10016 (Dr. Kutt).

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