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Intravenous Diphenylhydantoin in Experimental SeizuresI. Correlation of Dose, Blood, and Tissue Level in Cats
Henn Kutt, MD;
Sydney Louis, MD;
Fletcher McDowell, MD
Arch Neurol. 1968;18(5):465-471.
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DIPHENYLHYDANTOIN, used orally, is one of the most effective drugs available for the prevention of seizures. The oral or intramuscular routes of administration require the passage of hours to days, however, to achieve therapeutic blood levels, even when large loading doses are used.1-5 For these reasons, the availability of an intravenous preparation of diphenylhydantoin for status epilepticus, was welcomed. Recent studies from our laboratories, showed that as much as 1,000 mg could be given safely to patients by the intravenous route, provided certain precautions were observed.6 Well-sustained blood levels of diphenylhydantoin were achieved rapidly with this dosage without producing deep sedation.
However, only limited success has been achieved with the use of intravenous di-phenylhydantoin in status epilepticus in man.2,6,7 Controversy exists in the reported effects of the drug in stopping experimental seizures in animals.8,9 In an effort to understand the reasons for failure or
. . . [Full Text PDF of this Article]
Author Affiliations
New York
From the Second (Cornell) Neurology Service, Bellevue Hospital, and the Department of Neurology in Medicine, Cornell University Medical College, New York.
Footnotes
Submitted for publication Nov 30, 1967; accepted Dec 16.
Reprint requests to Second (Cornell) Neurology Service, Bellevue Hospital, First Ave and 26th St, New York 10016 (Dr. Kutt).
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