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The Initial Neurologic Manifestations

Allen Silverstein, MD

Arch Neurol. 1968;18(4):358-362.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THROMBOTIC thrombocytopenic purpura (TTP) is an unusual disease manifested clinically by hemolytic anemia, thrombocytopenia, fever, renal involvement and neurologic manifestations, and characterized pathologically by occlusion of small blood vessels in many organs by an homogenous, eosinophilic matter. While the disease is unusual and its etiology is unknown, the condition can no longer be considered rare. Table 1 is a summary of the number of patients with TTP reported since 1925 when the disease was first described.¹ The last review² of TTP, published in March 1966, collected 271 cases from the literature. Since then we have found more than 30 new published cases.

Neurologic involvement occurs in over 90% of patients with TTP,² and the illness begins as a neurologic one in 47%¹² to 60%³ of patients with TTP. Since 1947,⁵ almost all reviewers of this interesting disease have reported that the initial neurologic . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Neurology, Mount Sinai Hospital, New York, NY.

Footnotes
Submitted for publication Sept 13, 1967; accepted Oct 6.

Read before the 92nd annual meeting of the American Neurological Association, Atlantic City, NJ.

Reprint requests to Department of Neurology, Mount Sinai Hospital, 100th St and Fifth Ave, New York 10029 (Dr. Silverstein).

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