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The Influence of Cerebrospinal Fluid

R. W.P. Cutler, MD; A. V. Lorenzo, PhD; C. F. Barlow, MD

Arch Neurol. 1968;18(3):316-323.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT HAS been proposed¹ that the cerebrospinal fluid (CSF) acts as a "sink" for the brain extracellular space (ECS). Assuming free diffusion between brain ECS and CSF, the more rapid rate of removal of the extracellular indicator from the CSF relative to its rate of entrance into the CSF and brain from blood would prevent the attainment of a concentration equilibrium between the brain ECS and plasma. The "space" calculated with reference to the plasma concentration would, therefore, be smaller than the maximal anatomical volume of distribution of the indicator.

The present experiments were designed to eliminate the effect of the CSF "sink" by experimentally maintaining an equivalent concentration of isotope in plasma and CSF. This was accomplished by an intravenous injection and simultaneous ventriculocisternal perfusion of carrier-free sodium sulfate S35 and sodium iodide 1125 in ureter ligated cats. Perfusate concentration of tracers was adjusted to equal . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Children's-Peter Bent Brigham Unit of the Department of Neurology, Harvard Medical School, Boston.

Footnotes
Submitted for publication July 11, 1967; accepted Sept 11.

Read before the 42nd annual meeting of the American Association of Neuropathologists, Washington, DC, June 12, 1966.

Reprint requests to 300 Longwood Ave, Boston 02115 (Dr. Cutler).

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