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Allan L. Sherwin, MD, PhD; Francis E. LeBlanc, MD, PhD; William P. McCann, MD

Arch Neurol. 1968;18(3):311-315.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

NEOPLASMS have been shown to have different metabolic characteristics than normal tissues. Warburg¹ observed a greater tendency to derive energy from anaerobic glycolysis with the production of increased amounts of lactic acid. He later suggested that an early step in the development of a neoplasm was a disturbance in cellular respiratory activity.² Heller and Elliott showed that the rate of glycolysis was higher in human brain tumors than in normal gray matter when considered in relation to their respiratory rate.³ Hill and Levi⁴ noted that lactic dehydrogenase (LDH), the enzyme at the end of the metabolic chain of anaerobic glycolysis, was elevated in the serum of some patients with neoplastic disease. Increased amount of lactate and LDH have been found in brain tumor homogenates.⁵

In recent years it has been shown that the LDH activity of serum or tissue extracts is not . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Neurology and Neurosurgery, McGill University and the Montreal Neurological Institute, Montreal.

Footnotes
Submitted for publication July 21, 1967; accepted Aug 4.

Reprint requests to Montreal Neurological Institute, 3801 University St, Montreal 2 (Dr. Sherwin).

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