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Experimental Demonstration in Vivo

Richard L. Witcofski, PhD; C. Douglas Maynard, MD; Richard Janeway, MD

Arch Neurol. 1968;18(3):301-303.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN AN earlier paper¹ we described the apparent visualization of the choroid plexus on brain scans utilizing sodium pertechnetate Tc^99m. Orally administered potassium perchlorate had been shown to block the active concentration of^99mTc by the thyroid gland, stomach, and salivary glands.^2-4 We found that 200 mg of potassium perchlorate administered one hour before brain scanning apparently blocked the accumulation of^99mTc by the choroid plexus (Fig 1). Since perchlorate blocked this uptake, we reasoned that the observations presented convincing, inferential evidence of an active concentration process for^99mTc by the choroid plexus. We have performed experiments on rabbits in an attempt to evaluate the hypotheses that the choroid plexus actively concentrates the pertechnetate ion above blood levels and that this accumulation can be blocked by perchlorate.

Materials and Methods

Eighteen rabbits weighing between 1.8 and 2.2 kg (4 and 5 lb) were . . . [Full Text PDF of this Article]

Author Affiliations
Winston-Salem, NC

From the departments of radiology and neurology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC. Dr. Maynard is a James Picker fellow in radiological research.

Footnotes
Submitted for publication Aug 25, 1967; accepted Sept 25.

Reprint requests to Department of Radiology, Bowman Gray School of Medicine, Wake Forest University, 300 S Hawthorne Rd, Winston-Salem, NC 27103 (Dr. Witcofski).

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