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Production of Seizure Discharges

Irving H. Wagman, PhD; Rudolph H. de Jong, MD; David A. Prince, MD

Arch Neurol. 1968;18(3):277-290.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ALTHOUGH the actions of local anesthetics on the peripheral nervous system have been studied in detail for a number of years,^1-6 only relatively recently has attention been focused on the central effects produced when these agents are given intravenously. This recent interest is due in great measure to the current use of lidocaine (Xylocaine) as an anticonvulsant^7-9 and as an adjunct in general anesthesia.^10-12 An action of the local anesthetics which is difficult to relate to these effects is the production of convulsions in animals^9,13-16 and man^17,18 when higher doses are administered.

The effects of intravenously administered lidocaine and other local anesthetics on the electroencephalogram recorded from the surface have been described in cat,¹³ rabbit,¹⁶ monkey,⁹ and man.^18,19 The effects of the drug upon subcortical activities have not been thoroughly studied. Lesse and Gault²⁰ described an alteration in amygdaloid . . . [Full Text PDF of this Article]

Author Affiliations
Davis, Calif; Seattle; Palo Alto, Calif

From the Biomechanics Laboratory and Department of Anesthesia, University of California School of Medicine, San Francisco (Drs. Wagman and de Jong), the National Center for Primate Biology and the Department of Animal Physiology, University of California at Davis (Dr. Wagman), and the Division of Neurology, Stanford University School of Medicine, Palo Alto, Calif (Dr. Prince). Dr. de Jong is now at the Department of Anesthesiology, University of Washington School of Medicine, Seattle.

Footnotes
Submitted for publication July 13 1966; accepted Oct 16, 1967.

Read in part before the 17th annual meeting of the American EEG Society, San Francisco, Oct 1963, and before the Conference on Neurophysiology and Its Relations to Anesthesia, Seattle, 1966.

Reprint requests to National Center for Primate Biology, University of California, Davis, Calif (Dr. Wagman).

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