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Masao Kinoshita, MD; Thomas E. Cadman, MD

Arch Neurol. 1968;18(3):265-271.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN 1966 Spiro et al¹ reported an unusual myopathy in an adolescent boy with facial diplegia, external ocular palsy, and symmetrical muscle weakness. Since the morphological changes in the muscle biopsy resembled myotubes, the disease was named "myotubular myopathy." Recently Sher et al² reported two siblings with similar pathological features. In this paper the clinical and pathological findings in another case are presented. In addition, the histological and cytological findings in muscle from three fetuses are described.

Methods

Biopsy specimens were removed from the quadriceps femoris muscle of the patient in July and October 1966. On both occasions one muscle block was fixed in Bouin's solution, and another was frozen in isopentane cooled to —160 C by liquid nitrogen. The fixed sections were stained with hematoxylin and eosin, hematoxylin van Giesen, Gomori trichrome, PAS, Feulgen stain, and Lillie's allochrome techniques. The frozen sections were studied for . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the departments of neurology and pediatrics, University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia.

Footnotes
Submitted for publication June 3, 1967; accepted Sept 15.

Reprint requests to 1740 Bainbridge St, Philadelphia 19146 (Dr. Cadman).

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