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Problems in Laboratory Diagnosis

Richard T. Johnson, MD; Lloyd C. Olson, MD; Edward L. Buescher, MD

Arch Neurol. 1968;18(3):260-264.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

HERPES SIMPLEX virus Herpesvirus hominis) has recently attracted the increasing attention of neurologists. Formerly thought to be a rare cause of central nervous system (CNS) disease, this agent is now recognized as the most common cause of sporadic fatal encephalitis in this country.^1-3 Further, a recent clinical and laboratory analysis⁴ would confirm the suggestion of others^3-7 that herpes simplex encephalitis can present with unique clinical features, as well as a characteristic pathological involvement of the orbital-frontal and medial-temporal areas of the brain. The proposals that herpes simplex virus may play an etiologic role in subacute inclusion body encephalitis⁸ and acute hemorrhagic leucoencephalitis⁹ have further stimulated neurological interest in this agent. However, implication of the herpes simplex virus in the causation of any of these disorders must depend ultimately upon valid laboratory studies.

Three laboratory methods have been employed to establish a diagnosis of herpes . . . [Full Text PDF of this Article]

Author Affiliations
Cleveland

From the Department of Medicine (Division of Neurology), Cleveland Metropolitan General Hospital and Case Western Reserve University, School of Medicine, Cleveland, and the Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, DC.

Footnotes
Submitted for publication Aug 14, 1967; accepted Sept 22.

Reprint requests to 3395 Scranton Rd, Cleveland 44109 (Dr. Johnson).

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